I’m a big fan of using PWAs created with safari (yeah, much better than Chrome-based), but I haven’t found an ad blocking as effective as ublock origin like in firefox. So far I’m using adguard (free) on safari for brower-level blocking and nordvpn (paid) threat protection for dns-level blocking.
Still, that leaves some blank space where the ads used to exist, and it’s atheistically less than desirable.
With 1Blocker you can manually hide whitespace for a given site. But I only that for sites I visit every day.
I guess it boils down to what you dislike the most, Firefox/Chrome or whitespace and occasional ads. For me, I decided to stick with Safari because I really like using Safari.
Adguard is making Safari 2slow for my liking i just add Userscript for simple js/css/html blocker if needed (youtube and reddit for example). And have adguard home to block dns ads.